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  1. Ankylosing Spondylitis For AS, the dosage of celebrex is 200 mg daily in single (once per day) or divided (twice per day) doses. Warning, rISK OF celebrex side effects serious cardiovascular AND gastrointestinal events. Renal Impairment In a cross-study comparison, celecoxib AUC was approximately 40 lower in patients with chronic renal insufficiency (GFR 35-60 mL/min) than that seen in subjects with normal renal function.